Than two fold the normal amount while brush their teeth. Research shows that 10% kids swallow toothpaste more The most common source of fluoride ingestion into the humanīody. Pesticides, insecticides, and fertilizers. Masala (with tobacco and without tobacco), and residues of Products (toothpaste and mouth rinses), pediatric supplements,īeverages prepared with fluoridated water, tea, tobacco, pan Including water, medicines, dental restorative materials, dental HumansĪre exposed to sodium fluoride (NaF) from different sources Sodium fluoride, fluorosilicicĪcid or sodium fluorosilicate, and sodium mono fluorophosphateĪre the common compounds of fluoride being utilized. Additional studies must be warranted.įluorine (F) and aluminum (Al) are widely used in additives.įluorine commonly appears as fluoride ion (F-) that reacts with However, wet lab experiments areīeyond our scopes to validate the binding networks. Have been identified, including proteins (9 out of 19) associated with neurodegenerative disorders. We have found 86 indirect targets for F- and 90 for Al3+. In addition, protein-protein interaction has been explored to find the proteins that Interact with fluoride and 10 with aluminum).

We have identified 20 different proteins that directly bind with them (10 Here, we have screened for the human protein targets subjected to F- andĪl3+ interactions by using data-driven prediction tools. However, their target proteins have never been reported. Several studies show the detrimental effects posed by them including Alzheimer's disease. Such unwanted interactions affect the normal biological function of the target proteins, as well as theirĭownstream protein-protein interactions. But they can bind with proteins that interact with They don't have any known biological function. Previous studies showed that prolonged exposure to fluoride (F-) and aluminum (Al3+) ions is associated with numerous diseases

Aluminum reactivity with water proteins